Wednesday, 22 September 2010

Eczema classification

Source: Wikipedia

Eczema is a form of dermatitis, or inflammation of the epidermis. In England, one in nine have been diagnosed with eczema.

The term eczema is broadly applied to a range of persistent skin conditions. These include dryness and recurring skin rashes that are characterized by one or more of these symptoms: redness, skin oedema (swelling), itching and dryness, crusting, flaking, blistering, cracking, oozing, or bleeding. Areas of temporary skin discoloration may appear and are sometimes due to healed injuries.

Eczema may be confused with urticaria. In contrast to psoriasis, eczema is often likely to be found on the flexor aspect of joints.

In some languages, dermatitis and "eczema" are synonymous, while in other languages "dermatitis" implies an acute condition and "eczema" a chronic one. The two conditions are often classified together.

Classification

The term eczema refers to a set of clinical characteristics. Classification of the underlying diseases has been haphazard and unsystematic, with many synonyms used to describe the same condition. Many sources use the term eczema and the term for the most common type of eczema (atopic eczema) interchangeably.

The classification below is ordered by incidence frequency.

Common

  • Atopic eczema (a.k.a. infantile eczema, flexural eczema, atopic dermatitis) is an allergic disease believed to have a hereditary component and often runs in families whose members also have asthma. Itchy rash is particularly noticeable on head and scalp, neck, inside of elbows, behind knees, and buttocks. Experts are urging doctors to be more vigilant in weeding out cases that are, in actuality, irritant contact dermatitis. It is very common in developed countries, and rising.
  • Contact dermatitis is of two types: allergic (resulting from a delayed reaction to some allergen, such as poison ivy or nickel), and irritant (resulting from direct reaction to a detergent, such as sodium lauryl sulfate, for example). Some substances act both as allergen and irritant (wet cement, for example). Other substances cause a problem after sunlight exposure, bringing on phototoxic dermatitis. About three quarters of cases of contact eczema are of the irritant type, which is the most common occupational skin disease. Contact eczema is curable, provided the offending substance can be avoided and its traces removed from one’s environment.
  • Xerotic eczema (aka asteatotic eczema, eczema craquele or craquelatum, winter itch, pruritus hiemalis) is dry skin that becomes so serious it turns into eczema. It worsens in dry winter weather, and limbs and trunk are most often affected. The itchy, tender skin resembles a dry, cracked, river bed. This disorder is very common among the older population. Ichthyosis is a related disorder.
  • Seborrhoeic dermatitis ("cradle cap" in infants) is a condition sometimes classified as a form of eczema that is closely related to dandruff. It causes dry or greasy peeling of the scalp, eyebrows, and face, and sometimes trunk. The condition is harmless except in severe cases of cradle cap. In newborns it causes a thick, yellow crusty scalp rash called cradle cap, which seems related to lack of biotin and is often curable.
Less common

  • Dyshidrosis (aka dyshidrotic eczema, pompholyx, vesicular palmoplantar dermatitis, housewife’s eczema) only occurs on palms, soles, and sides of fingers and toes. Tiny opaque bumps called vesicles, thickening, and cracks are accompanied by itching, which gets worse at night. A common type of hand eczema, it worsens in warm weather.
  • Discoid eczema (a.k.a. nummular eczema, exudative eczema, microbial eczema) is characterized by round spots of oozing or dry rash, with clear boundaries, often on lower legs. It is usually worse in winter. Cause is unknown, and the condition tends to come and go.
  • Venous eczema (a.k.a. gravitational eczema, stasis dermatitis, varicose eczema) occurs in people with impaired circulation, varicose veins and oedema, and is particularly common in the ankle area of people over 50. There is redness, scaling, darkening of the skin and itching. The disorder predisposes to leg ulcers.
  • Dermatitis herpetiformis (aka Duhring’s Disease) causes intensely itchy and typically symmetrical rash on arms, thighs, knees, and back. It is directly related to coeliac disease, can often be put into remission with appropriate diet, and tends to get worse at night.
  • Neurodermatitis (aka lichen simplex chronicus, localized scratch dermatitis) is an itchy area of thickened, pigmented eczema patch that results from habitual rubbing and scratching. Usually there is only one spot. Often curable through behaviour modification and anti-inflammatory medication. Prurigo nodularis is a related disorder showing multiple lumps.
  • Autoeczematization (aka id reaction, autosensitization) is an eczematous reaction to an infection with parasites, fungi, bacteria or viruses. It is completely curable with the clearance of the original infection that caused it. The appearance varies depending on the cause. It always occurs some distance away from the original infection.
  • There are also eczemas overlaid by viral infections (e. herpeticum, e. vaccinatum), and eczemas resulting from underlying disease (e.g. lymphoma). Eczemas originating from ingestion of medications, foods, and chemicals, have not yet been clearly systematized. Other rare eczematous disorders exist in addition to those listed here.

Diagnosis of eczema is based mostly on history and physical examination. However, in uncertain cases, skin biopsy may be useful.

Prevention: Those with a family history of eczema are advised not to accept the smallpox vaccination, or anything else that contains live vaccinia virus.

Psoriasis pathology

Source: Robbins 840

Affects 1-3% of people.

Psoriasis is an immunologic disease with contributions from genetic susceptibility and genetic factors. It is not known if the inciting antigens are self or environmental.

Sensitised populations of T cells enter the skin, including dermal CD4+ TH1 cells and CD8+ T cells that accumulate in the epidermis.

T cells homing to the skin secrete cytokines and growth factors that induce keratinocyte hyper-proliferation, resulting in the characteristic lesions.

Psoriatic lesions can be induced in susceptible individuals by local trauma, a process known as the Koebner phenomenon. The trauma may induce a local inflammatory response that promotes lesion development.

Morphology

  • Marked epidermal thickening (acoanthosis).
  • Regular donward elongation of the rete ridges. This downward growth has been likened to test-tubes in a rack.
  • Increased epidermal cell turnover and lack of maturation results in loss of the stratum granulosum with extensive overlying parakeratotic scale.
  • There is thinning of the epidermal cell layer overlying the tips of dermal papillae (suprapapillary plates).
  • Blood vessels within the papillae are dilated and tortuous. These vessels bleed rapidly when the scale is removed, giving rise to multiple punctate bleeding points (Auspitz sign).
  • Neutrophils form small aggregates within both the spongiotic superficial epidermis (pustules of Kogoj) and the parakeratotic stratum corneum (Munro microabscesses).
  • Similar changes can be seen in superficial fungal infections, and it is important to exclude this possibility with special stains in new diagnoses of psoriasis.
Psoriasis most frequently affects the skin of the elbows, knees, scalp, lumbosacral areas, intergluteal cleft, glans penis.

The most typical lesion is a well-demarcated, pink plaque covered by loosely adherent silver-white scale.

Nail changes occur in 30% and consist of yellow-bown discoloration, with pitting, thicking and onycholysis (crumbling and separation of the nail bed from the underlying bed).

There are a variety of clinical subtypes.

Management of psoriasis

Source: Wikipedia

1. Cognitive behaviour therapy


2. Topical Rx

Bath solutions and moisturizers, mineral oil, and petroleum jelly may help soothe affected skin and reduce the dryness which accompanies the build-up of skin on psoriatic plaques. Ointments and creams containing coal tar, dithranol (anthralin), corticosteroids like desoximetasone (Topicort), fluocinonide, vitamin D3 analogues (for example, calcipotriol), and retinoids are routinely used. Argan oil has also been used with some promising results. The mechanism of action of each is probably different but they all help to normalise skin cell production and reduce inflammation. Activated vitamin D and its analogues are highly effective inhibitors of skin cell proliferation.

The disadvantages of topical agents are variably that they can often irritate normal skin, can be time consuming and awkward to apply, cannot be used for long periods, can stain clothing or have a strong odour. As a result, it is sometimes difficult for people to maintain the regular application of these medications. Abrupt withdrawal of some topical agents, particularly corticosteroids, can cause an aggressive recurrence of the condition. This is known as a rebound of the condition.

Some topical agents are used in conjunction with other therapies, especially phototherapy.

3. Phototherapy

Daily, short, non-burning exposure to sunlight helped to clear or improve psoriasis in some patients. Niels Finsen was the first physician to investigate the therapeutic effects of sunlight scientifically.

Ultraviolet wavelengths are subdivided into UVA (380–315 nm) UVB (315–280 nm), and UVC...

4. Photochemotherapy

Psoralen and ultraviolet A phototherapy (PUVA) combines the oral or topical administration of psoralen with exposure to ultraviolet A (UVA) light. Precisely how PUVA works is not known. The mechanism of action probably involves activation of psoralen by UVA light which inhibits the abnormally rapid production of the cells in psoriatic skin. There are multiple mechanisms of action associated with PUVA, including effects on the skin immune system.

PUVA is associated with nausea, headache, fatigue, burning, and itching. Long-term treatment is associated with squamous cell carcinoma (not with melanoma).

5. Systemic treatment

Psoriasis that is resistant to topical treatment and phototherapy is treated with systemic treatment. Patients undergoing systemic treatment are required to have regular blood and liver function tests because of the toxicity of the medication. Pregnancy must be avoided for the majority of these treatments. Most people experience a recurrence of psoriasis after systemic treatment is discontinued.

The three main traditional systemic treatments are methotrexate, cyclosporine and retinoids. Methotrexate and cyclosporine are immunosuppressant drugs; retinoids are synthetic forms of vitamin A.

Other additional drugs, not specifically licensed for psoriasis, have been found to be effective. These include the antimetabolites tioguanine, mercaptopurine and fluorouracil, the cytotoxic agents hydroxyurea and paclitaxel, alkylating agents chlorambucil and cyclophosphamide, some DMARDs like sulfasalazine, colchicine, dapsone, the immunosuppressants mycophenolate mofetil, azathioprine and oral tacrolimus. These have all been used effectively to treat psoriasis when other treatments have failed.

Although not licensed in many other countries, fumaric acid esters have also been used to treat severe psoriasis in Germany for over 20 years.

There is also some evidence for beneficial effect on psoriasis of insulin-sensitizing drugs (thiazolidinediones like pioglitazone and rosiglitazone, and a more modest effect is described for metformin), somatostatin, bromocriptine, and some lipid-lowering drugs from the group of statines (like simvastatin), and omega-3 fatty acid supplements. For all those drugs it is hypothesised that their antipsoriatic activity comes from their immunomodulatory properties.

There are also case reports and small trials describing beneficial effects of yohimbine (effect is thought to be secondary to its insulin-lowering and growth hormone lowering properties), ketotifen (effect is thought to be secondary to its ability to dampen release of inflammatory mediators) and albuterol (beta-adrenergic agonist).

Antihistamine drugs generally do not help to improve psoriasis lesions, but they may be of use to reduce itching and also are helpful in cases where psoriasis coexists with skin allergy, for example chronic urticaria. Some antihistamines have sedative properties, thus might aid to improve sleep and reduce anxiety in psoriasis patients.

Antidepressant medications may help to reduce comorbid depression, anxiety, social isolation, improve sleep and in some cases reduce itching (primarily due to antihistamine effects of tricyclic antidepressants and some SSRIs). Naltrexone, an opioid antagonist, and pregabalin or gabapentin, benzodiazepine anxiolytics are also of use in severe itching.

NSAIDs generally do not help to improve psoriatic arthritis itself, but they might provide rapid symptomatic relief from pain and swelling.

Biologics are manufactured proteins that interrupt the immune process involved in psoriasis. Unlike generalised immunosuppressant therapies such as methotrexate, biologics focus on specific aspects of the immune function leading to psoriasis. These drugs (interleukin antagonists) are relatively new, and their long-term impact on immune function is unknown, but they have proven effective in treating psoriasis and psoriatic arthritis. They include Amevive, Enbrel, Humira, Remicade and Raptiva. Raptiva was withdrawn by its maker from the US market in April, 2009. Biologics are usually given by self-injection or in a doctor's office. They are very expensive and only suitable for very few patients with severe psoriasis. Ustekinumab (IL-12 and IL-23 blocker) shows hopeful results for psoriasis therapy.

Noting that botulinum toxin has been shown to have an effect on inhibiting neurogenic inflammation, and evidence suggesting the role of neurogenic inflammation in the pathogenesis of psoriasis, the University of Minnesota has begun a clinical trial to follow up on the observation that patients treated with botulinum toxin for dystonia had dramatic improvement in psoriasis.

Classification of psoriasis

Source: Wikipedia

In contrast to eczema, psoriasis is more likely to be found on the outer side of the joint.
Some patients have no dermatological symptoms.
Local psoriatic changes can be triggered by an injury to the skin - Koebner phenomenon.

Psoriasis is classified into nonpustular and pustular types:

Non-pustular
  • Psoriasis vulgaris: a.k.a. plaque psoriasis. The most common type (80%-90% of patients). Raised areas of inflamed skin covered with silvery white scaly skin.
  • Psoriatic erythroderma: Inflammation and exfoliation of skin over most of the body. May be accompanied by severe itching, swelling and pain. It is often the result of an exacerbation of unstable plaque psoriasis, particularly following the abrupt withdrawal of systemic Rx. Can be fatal, as the extreme inflammation and exfoliation disrupt the body's ability to regulate temperature and for the skin to perform barrier functions.
Pustular

Pustular psoriasis appears as raised bumps filled with non-infectious pus (pustules). The skin under and surrounding the pustules is red and tender. Can be localised, commonly to the hands and feet (palmoplantar pustulosis), or generalised with widespread patches occurring randomly on any part of the body. This classification includes:
  • Generalised pustular psoriasis (of von Zumbusch)
  • Pustulosis palmaris et plantaris
  • Annular pustular psoriasis
  • Acrodermatitis continua
  • Impetigo herpetiformis (a form of severe pustular psoriasis occurring in pregnancy).


Other

  • Drug-induced.
  • Inverse psoriasis, a.k.a. flexural psoriasis. Occurs in skin folds, particularly around the genitals (between the thigh and groin), armits under an overweight stomach (pannus) under the breasts (inframammary fold). Aggravated by friction and sweat, and is vulnerable to fungal infections.
  • Napkin psoriasis.
  • Seborrhoeic-like psoriasis.
  • Guttate psoriasis: Numerous small, scaly, red/pink, teardrop-shaped lesions over large areas of the body, primarily the trunk (also limbs and scalp). Often preceded by a streptococcal infection, typically streptococcal pharyngitis.
  • Nail psoriasis: Discolouring, pitting, lines going across the nails, thickening of skin under nail, loosening and crumbling of the nail (onycholysis).
  • Psoriatic arthritis: Joint and connective tissue inflammation. Can affect any joint but most common in the joints of fingers and toes. Can result in sausage-shaped swilling of fingers/toes (dactylitis). Can also affect the hips, knees and spine (spondylitis). 10%-15% of people with psoriasis have psoriatic arthritis.